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Malaria Links

Foundations and Organizations

NIAID - The National Institute of Allergy and Infectious Disease Malaria Research Program. Malaria continues to be the most important tropical parasitic disease in terms of annual mortality, making it a high-priority NIAID research area.

TDR - "To foster an effective global research effort on infectious diseases of poverty in which disease endemic countries play a pivotal role." TDR enables, supports and prioritizes tropical disease research worldwide.

The Bill & Melinda Gates Foundation was created to help reduce inequities around the world by increasing opportunity and equity for those most in need. Malaria funding targets treatment and prevention toward eradication of the disease.

PATH Malaria Vaccine Initiative (MVI) is a focused vaccine development program which provides funding and technical support to partners worldwide to accelerate the development of malaria vaccines.

RBM, Roll Back Malaria Partnership, was launched in 1998 by the WHO, UNICEF, the United Nations Development Programme (UNDP) and the World Bank to provide a coordinated global approach to fighting malaria

DNDi strives "To improve the quality of life and the health of people suffering from neglected diseases by using an alternative model to develop drugs for these diseases and ensuring equitable access to new and field relevant health tools."

MMV, Medicines for Malaria Venture, is a nonprofit organization created to discover, develop and deliver new antimalarial drugs through effective public-private partnerships.

The Wellcome Trust is one of the world's leading supporters of research in tropical medicine.

African Malaria Network Trust, AMANET.The mission of AMANET is to "Promote Capacity Strengthening and Networking of Malaria Research and Development in Africa."

Malaria Consortium is an organisation dedicated to improving delivery of prevention and treatment to combat malaria and other communicable diseases in Africa and Asia.

Malaria Foundation International is a non profit organization to support awareness, education, training, research, and leadership programs for the immediate and long term development and application of tools to combat malaria.

The Centers for Disease Control; CDC's mission is "to promote health and quality of life by preventing and controlling disease, injury, and disability."

NIMR (ICMR) in Delhi, India, formerly Malaria Research Centre. The primary task of NIMR is to find short term as well as long term solutions to the problems of malaria through basic, applied and operational field research.

MIM is an alliance of organizations and individuals working together to maximize the impact of scientific research on malaria through strengthening African research capacity for participation in the development of treatment and control tools.

Laboratories and Protocols

Johns Hopkins Malaria Research Institute (JHMRI) research program at Johns Hopkins School of Public Health. Site outlines current malaria research progress with background details of the disease, FAQ, and details of other research projects.

NIAID Laboratory of Malaria and Vector Research and Malaria Vaccine Development Branch...

Leiden University Medical Center Malaria Research Group, with expertise in the Plasmodium berghei rodent model of malaria houses basic and advanced protocols for rodent malaria research. Many plasmids and strains are available from MR4.

Walter Reed Biosystematics Unit (WRBU) conducts systematics research on medically important arthropods and maintains a U.S. government mosquito collection. The Culicidae mosquito catalog curates systematics, distribution and references.

Malaria and Tropical Disease Journal

PubMed, a service of the National Library of Medicine, includes over 17 million citations from MEDLINE and other life science journals for biomedical articles back to the 1950s. PubMed Links to full text articles including open access...

Malaria Journal, a BioMed Central publication, provides open access to peer-reviewed malaria research. It is the only journal that publishes exclusively papers on malaria research advances.

The American Journal of Tropical Medicine and Hygiene is a subscription-based peer-reviewed journal from the American Society of Tropical Medicine and Hygiene with significant focus on malaria and other infectious disease research.

Trends in Parasitology commissions articles of broad interest written in a form accessible to readers in other fields.

Molecular and Biochemical Parasitology publishes investigations of the molecular biology and biochemistry of parasitic protozoa and their interactions with both the definitive and intermediate hosts.

Vector-Borne and Zoonotic Diseases , a journal dedicated to diseases transmitted to humans by insects or animals covering ecology, entomology, epidemiology, infectious disease, microbiology, parasitology, pathology, public health risk and...

Infection and Immunity, an ASM journal, focuses on host-pathogen interactions and encompasses a wide range of topics of interest to microbiologists, immunologists, epidemiologists, pathologists, and clinicians.

PLoS Pathogens is an open-access, peer-reviewed journal published monthly by the Public Library of Science (PLoS), a nonprofit organization. Publishes reasearch that advances the understanding of pathogens and pathogen-host...

Nature's Plasmodium sequence papers are available free online in perpetuity. Related content from Nature's malaria special issues is also available.

Malaria Research Resources

CDC Malaria home page with links to global health status, disease control and prevention, traveler information, epidemiology, biology and research.

The WHO Global Malaria Programme (GMP) is responsible for malaria surveillance, monitoring and evaluation, policy and strategy formulation, technical assistance and coordination of WHO's global efforts to fight malaria.

The Wellcome Trust global malaria news page. The Wellcome Trust supports research and initiatives that aim to tackle the huge burden of malaria in the developing world.

MalariaGEN brings together research groups to work together on large-scale investigations. The MalariaGEN Resource Centre is a collaboration of Oxford University and Wellcome Trust Sanger Institute

WorldWide Antimalarial Resistance Network (WWARN) is a global collaboration working to ensure that anyone affected by malaria receives effective and safe drug treatment

WHO - World Health Organization Malaria health topics page includes Fact Sheets, data and statistics and WHO world malaria reports.

MAP - Malaria Atlas Project. This project aims to develop a detailed model of the spatial limits of Plasmodium falciparum and P. vivax malaria at a global scale and its endemicity within this range. Principally funded by the Wellcome Trust.

National Library of Medicine (NLM). MIMCom, a Multilateral Initiative on Malaria (MIM) project supported by the NLM enabled internet connectivity in 12 African nations. NLM continues to provide database support to aid malaria research.

Vivaxmalaria.com, a website for general information (biology, prevalence, genomics, history), reagents, resources, images, articles and conference information concerning Plasmodium vivax. Developed by Jane Carlton (NYUSM) and colleagues.

BiomalPar - "Biology and Pathology of Malaria Parasite"- is a Network of Ecellence funded by the European Commission as part of its 6th Framework programme. This network is co-ordinated by the Institut Pasteur - Paris

Click genus name for Plasmodium News or Anopheles...

The CDC's Malaria Risk Map Application, an interactive map which provides information on malaria throughout the world.

Molecular Reference Databases

Chemical Databases

PubChem at NLM provides information on the biological activities of small molecules, and is a component of NIH's Molecular Libraries Roadmap Initiative. Useful for antimalarial discovery research.

Medical Structural Genomics of Pathogenic Protozoa - project focused on high throughput protein analysis toward structure determination for identification of antiparasitic lead compounds against known metabolic targets. See MRA-836 plasmids.

Metabolic Pathways

Malaria Parasite Metabolic Pathways maintained by Hagai Ginsburg. This site provides a gateway to biochemical and metabolic information that complements the genetic information developed for the Plasmodium falciparum parasite.

Proteome and Microarrays

Malaria IDC Strain Comparison Database for Plasmodium falciparum 3D7, HB3 and Dd2 strain transcriptomes, hosted by DeRisi and colleagues at UCSF.

The SGPP program initiated projects toward three-dimensional structures for a large set of proteins from pathogenic protozoa including Leishmania major, Trypanosoma brucei, Trypanosoma cruzi and Plasmodium falciparum. See also MSGPP.

Publications

NCBI provides data and information relevant to malaria genetics and genomics. These resources include organism specific cross-referenced sequence databases, genome maps, linkage markers, and PubMed literature searches.

Sequence Databases

The CDC's Malaria Risk Map Application, an interactive map which provides information on malaria throughout the world.

PlasmoDB hosts genomic, proteomic, metabolomic and molecular data for Plasmodium species.

AnoBase databases compile genomic/biological information on anopheline mosquitoes, with an emphasis on Anopheles gambiae. AnoBase is the continuation of AnoDB.

The Gene Index databases for Plasmodium spp. integrate research data from international Plasmodium EST sequencing and gene research projects. Hosted by Dana-Farber Cancer Institute and Harvard School of Public Health with support from NSF.

VectorBase- A. gambiae Data from Ensembl and Vectorbase joint whole genome shotgun assembly (AgamP3) of the PEST strain of Anopheles gambiae, as prepared by The International Anopheles Genome project.

Ensembl Anopheles gambiae data are made possible through a joint effort by the Ensembl group and VectorBase. Genome assembly AgamP3 (Feb. 2006) is based on the whole genome shotgun assembly of A. gambiae PEST strain.

GeneDB, maintained by The Wellcome Trust Sanger Institute Pathogen Sequencing Unit

TIGR (now JCVI) hosted sequencing projects for the International Malaria Genome Sequencing Consortium. Genome sequencing database archives remain available for Plasmodium falciparum genomic libraries.

ApiDB/EuPathDB Bioinformatics Resource Center for Biodefense and Emerging/Re-emerging Infectious Diseases, portal to access genomic-scale datasets for eukaryotic pathogens including select apicomplexan, kinetoplastid and enteric parasite spp.

More parasite genome database links and genome research resources from EMBL-EBI.

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MR4 is funded by the National Institute of Allergy and Infectious Diseases and managed by ATCC