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Plasmodium falciparum piggyBac Insertion Mutants Now Available
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From the laboratory of John Adams, we now have over 100 piggyBac insertion mutants available, complete with mapped insertion sites. The list of currently available clones is HERE. Please place your request for individual mutants by specifying the MR4 number (column 1 on the spreadsheet) and Clone ID number (column 4) to malaria@atcc.org. Clones will be listed as separate reagents by MR4 number in the MR4 and BEI Resources catalogs in the near future.
Balu B,et al. High-efficiency transformation of Plasmodium falciparum by the lepidopteran transposable element piggyBac. Proc Natl Acad Sci U S A. 102: 16391-16396, 2005. PubMed: 16260745
Balu B, et al. piggyBac is an effective tool for functional analysis of the Plasmodium falciparum genome. BMC Microbiol. 9: 83, 2009. PubMed: 19422698
Balu B, et al. A genetic screen for attenuated growth identifies genes crucial for intraerythrocytic development of Plasmodium falciparum. PLoS One. 5: e13282, 2010. PubMed: 20949012
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HC-04 Hepatocyte Cell LIne (MRA-975) now available
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The HC-04 hepatocyte cell line, MRA-975, supports sporozoite development to liver and blood stages in short term in vitro culture for Plasmodium falciparum and Plasmodium vivax. Deposited by Jetsumon Sattabongkot at AFRIMS.
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Placental Malaria Histology Microscopy Slides For Training
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MR4 has acquired a limited number of Placental Malaria Histology Microscopy Slide Sets for training purposes, available on loan for BEI registered investigators. For the full announcement and application instructions, click HERE or go directly to the microscopy training information and application instructions page. Our thanks to Atis Muehlenbachs at the University of Washington for his extensive work on preparing these sets and documentation for MR4.
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Welcome - MR4 Portal Information
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We are restructuring the MR4 Web portal to better serve the malaria research community. Please bear with us as we work to improve this site. If you experience any difficulty accessing information or otherwise using this site, send an email with the description of the problem and the internet page address you were on at the time to: malaria@atcc.org.
Content and Site Changes
MR4 has integrated with NIAID BEI Resources! MR4 program operations have merged with the other NIAID Infectious Diseases repositories in the NIAID BEI program under the NIAID MID-BRR contract. Most of the content from the previous MR4 web site is available in these MR4 collection portal pages. If you are a currently registered BEI user, program operations remain unchanged. New users should review all BEI program information. Links for registering, ordering and depositing materials with the MR4 collection in the BEI Resources program can be found under the “Forms” key in the “Program Information” menu.
The MR4 News and Announcements section has moved to the “Highlights” section on the left panel. “Quick Links” guides you to commonly accessed tools on the MR4 web. To access additional Highlights and Quick Links, click the "View all" button for each section. External Malaria research links can be found on the right side of the menu bar and right side of the home page.
If you have a slower internet connection or experience slow page loading, please select the “Low Bandwidth” connection on the lower right side of the home page to reduce graphics content within the MR4 web portal. You can return to full content by reselecting the “High Bandwidth” button on the home page when in “Low Bandwidth” mode. Please note that “Low Bandwidth” mode has no effect on MR4 web portal content accessed through external sites or linked malaria resources web content stored at external sites.
Please send feedback or questions to malaria@atcc.org, and thank you for supporting the MR4!
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Now Available
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New reagents will be linked HERE on the MR4 reagents home page top menu tab.
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Important Announcement – MR4 Now Part of NIAID’s BEI Resources
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The NIAID MR4 program has been your go-to resource for malaria repository reagents for nearly 12 years. As part of the integration and consolidation of the NIAID “specialized collections” of biological repositories, the MR4 reagent collection is now supported by DMID’s Microbiology and Infectious Diseases Biological Research Resources Program as one of the NIAID BEI Resources collections, managed by ATCC. The BEI Resources program provides access to NIAID’s diverse array of infectious diseases repository collections and will include all MR4 items.
Registration with BEI Resources will allow you to continue ordering MR4 reagents and grant access to reagents across the NIAID repositiories included in this program. Furthermore, you will now be able to order MR4 reagents online.
Thank you for your continued support of NIAID’s MR4 collection and we look forward to serving your needs under the expanded scope of the NIAID BEI Resources collections.
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What's New
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Announcements on New MR4 Reagents, Activities and Information
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